Designing online social interaction for and with older people

This thesis describes my explorations and reflections regarding the design of online social interaction for and with older people. In 2008 when I started my doctoral investigation only a third of people over 65 years in the UK were using the Internet. This number has now increased to half of the population of 65-75 year-olds being connected to the Internet. From 2000 onwards EU wide directives increasingly encouraged research in the development of online technologies to manage the needs of an ageing population in the EU. Alongside health-related risks, the issue of social isolation is of particular interest to be tackled, considering there is a rapid development of new forms of communication and interaction media based on online technologies that could help in maintaining contact between people. A beneficial design strategy is to involve older people in the design process to ensure that technological developments are welcomed and actually used. However, engaging older people, who are not necessarily familiar with digital technologies, is not without challenges for the design researcher. My research focuses both on design practice (the development of artefacts) and the design process for online social interaction involving older people. The thesis describes practice-led research, for which I built the Teletalker (TT) and Telewalker (TW) systems as prototypes for experimentation and design research interventions. The TT can be described as a simple TV like online audio-video presence system connecting two locations. The TW is based on the same concept has been built specifically for vulnerable older people living in a care home. The work described involves embodied real-world interventions with contemporary approaches to designing with people. In particular I explore the delicate nature of the researcher/participant relationship. The research is reported as four sequential journeys. The first design journey started from a user-centred iterative design perspective and resulted in the construction of a wireframe for a website for older users. The second journey focused on building the TT and investigated its use in the real world by people with varied computer experience. The third journey involved designing the TW system specifically for elderly people in a care home. The fourth journey employed a co-design approach, with invited stakeholders, to reflect on the physical artefacts, discuss narratives of the previous design journeys and to co-create new online social technologies for the future. In summary, my PhD thesis contributes to design theory by providing: a reflected rationale for the choices of design approaches, documented examples of design research for social interaction and a novel approach to research with older people (the extended showroom). It further offers insights into people's online social interaction and proposes guidelines for conducting empirical research with older and vulnerable older people

Tracking Down South Branch House: A Critical Look at the Identification of the Hudson’s Bay Company’s South Branch House (FfNm-1)

The late Arthur Silver Morton has contributed immensely to our understanding and preservation of western Canadian history. One of Morton’s joys was locating remains of long forgotten fur trade posts. As a result, a large number of the Saskatchewan fur trade posts that we know of were located and recorded by Morton. The majority of Morton’s investigations took place throughout the 1930s and 1940s. Morton consulted whatever historic sources were available to him at the time: numerous historic documents, ethnographic accounts and local histories. There has been archaeological evidence that suggests Morton misidentified numerous fur trade post sites. For example, research at the Hudson’s Bay Company’s South Branch House (1786-1794), which Morton identified in 1944, has sparked some controversy as to whether or not it is that particular post. As a result, this provides the author with an excellent chance to examine how Morton identified Saskatchewan fur trade posts and to determine through archaeological excavations and historical documents the accuracy of Morton’s historical site designation at South Branch House. A critical approach to Morton’s work will determine how accurate his work is for contemporary archaeological investigations of fur trade posts. Furthermore, this thesis may provide historical archaeologists with insights as to how to go about identifying fur trade posts, which will contribute to our overall understanding of the western Canadian fur trade

Dynamics of an Idealized Fluid Model for Investigating Convective-scale Data Assimilation

An idealized fluid model of convective-scale numerical weather prediction, intended for use in inexpensive data assimilation experiments, is described here and its distinctive dynamics are investigated. The model modifies the rotating shallow water equations to include some simplified dynamics of cumulus convection and associated precipitation, extending and improving the model of Würsch and Craig. Changes to this original model are the removal of ad hoc diffusive terms and the addition of Coriolis rotation terms, leading to a so-called 1.5-dimensional model. Despite the non-trivial modifications to the parent equations, it is shown that this shallow water type model remains hyperbolic in character and can be integrated accordingly using a discontinuous Galerkin finite element method for nonconservative hyperbolic systems of partial differential equations. Combined with methods to ensure well-balancedness and non-negativity, the resulting numerical solver is novel, efficient and robust. Classical numerical experiments in the shallow water theory, such as the Rossby geostrophic adjustment and flow over topography, are reproduced for the standard shallow water model and used to highlight the modified dynamics of the new model. In particular, it exhibits important aspects of convective-scale dynamics relating to the disruption of large-scale balance and is able to simulate other features related to convecting and precipitating weather systems. Our analysis here and preliminary results suggest that the model is well suited for efficiently and robustly investigating data assimilation schemes in an idealized ‘convective-scale’ forecast assimilation framework

Isolation, cohesion and contingent network effects: the case of school attachment and engagement

Isolation and cohesion are two key network features, often used to predict outcomes like mental health and deviance. More cohesive settings tend to have better outcomes, while isolates tend to fare worse than their more integrated peers. A common assumption of past work is that the effect of cohesion is universal, so that all actors get the same benefits of being in a socially cohesive environment. Here, we suggest that the effect of cohesion is universal only for specific types of outcomes. For other outcomes, experiencing the benefits of cohesion depends on an individual’s position in the network, such as whether or not an individual has any social ties. Network processes thus operate at both the individual and contextual level, and we employ hierarchical linear models to analyze these jointly to arrive at a full picture of how networks matter. We explore these ideas using the case of adolescents in schools (using Add Health data), focusing on the effect of isolation and cohesion on two outcomes, school attachment and academic engagement. We find that cohesion has a uniform effect in the case of engagement but not attachment. Only non-isolates experience stronger feelings of attachment as cohesion increases, while all students, both isolates and non-isolates, are more strongly engaged in high cohesion settings. Overall, the results show the importance of taking a systematic, multi-level approach, with important implications for studies of health and deviance

Aeroacoustic Study of a High-Fidelity Aircraft Model: Part 1- Steady Aerodynamic Measurements

In this paper, we present steady aerodynamic measurements for an 18% scale model of a Gulfstream air-craft. The high fidelity and highly-instrumented semi-span model was developed to perform detailed aeroacoustic studies of airframe noise associated with main landing gear/flap components and gear-flap interaction noise, as well as to evaluate novel noise reduction concepts. The aeroacoustic tests, being conducted in the NASA Langley Research Center 14- by 22-Foot Subsonic Tunnel, are split into two entries. The first entry, completed November 2010, was entirely devoted to the detailed mapping of the aerodynamic characteristics of the fabricated model. Flap deflections of 39?, 20?, and 0? with the main landing gear on and off were tested at Mach numbers of 0.16, 0.20, and 0.24. Additionally, for each flap deflection, the model was tested with the tunnel both in the closed-wall and open-wall (jet) modes. During this first entry, global forces (lift and drag) and extensive steady and unsteady surface pressure measurements were obtained. Preliminary analysis of the measured forces indicates that lift, drag, and stall characteristics compare favorably with Gulfstream?s high Reynolds number flight data. The favorable comparison between wind-tunnel and flight data allows the semi-span model to be used as a test bed for developing/evaluating airframe noise reduction concepts under a relevant environment. Moreover, initial comparison of the aerodynamic measurements obtained with the tunnel in the closed- and open-wall configurations shows similar aerodynamic behavior. This permits the acoustic and off-surface flow measurements, planned for the second entry, to be conducted with the tunnel in the open-jet mode

Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer’s disease, and epilepsy

Traumatic brain injury (TBI), Alzheimer’s disease (AD), and epilepsy share proposed mechanisms of injury, including neuronal excitotoxicity, cascade signaling, and activation of protein biomarkers such as tau. Although tau is typically present intracellularly, in tauopathies, phosphorylated (p-) and hyper-phosphorylated (hp-) tau are released extracellularly, the latter leading to decreased neuronal stability and neurofibrillary tangles (NFTs). Tau cleavage at particular sites increases susceptibility to hyper-phosphorylation, NFT formation, and eventual cell death. The relationship between tau and inflammation, however, is unknown. In this review, we present evidence for an imbalanced endoplasmic reticulum (ER) stress response and inflammatory signaling pathways resulting in atypical p-tau, hp-tau and NFT formation. Further, we propose tau as a biomarker for neuronal injury severity in TBI, AD, and epilepsy. We present a hypothesis of tau phosphorylation as an initial acute neuroprotective response to seizures/TBI. However, if the underlying seizure pathology or TBI recurrence is not effectively treated, and the pathway becomes chronically activated, we propose a “tipping point” hypothesis that identifies a transition of tau phosphorylation from neuroprotective to injurious. We outline the role of amyloid beta (Aβ) as a “last ditch effort” to revert the cell to programmed death signaling, that, when fails, transitions the mechanism from injurious to neurodegenerative. Lastly, we discuss targets along these pathways for therapeutic intervention in AD, TBI, and epilepsy

Archives of thrill: the V-Armchair experience

Technology for older people is typically concerned either with health care or accessibility of existing systems. In this paper we take a more ‘entertainment-oriented’ approach to developing experiences aimed at older users. We describe here the design, development and a user study of the V-Armchair, a virtual reality and motion platform based roller coaster experience. The V-Armchair constitutes a blueprint for the digital archiving of physical ride experiences through the simultaneous capture of 360 video, sound and motion. It gives access to thrill experiences to those who may not be able to go on real thrill rides, such as older riders, and it can be considered as a class of technology that could help to support ‘active aging’ as defined by the World Health Organisation. We discuss strategies for capturing and then ‘toning down’ motion experiences to make them accessible for older users. We present a study which explores the user experience of the V-Armchair with an older group (median age 63) using a DK2 headset, and a younger group (median age 25) using a CV1 headset, via thematic analysis of semi-structured interviews and a modified version of the Game Experience Questionnaire, and discuss emergent themes such as the role of the presenter, reminiscence, presence and immersion

GAMIBHEAR: whole-genome haplotype reconstruction from genome architecture mapping data

Motivation: Understanding haplotype-specific regulatory mechanisms becomes increasingly important in genomics and medical research. Investigating differences in allele-specific gene expression, epigenetic changes and their causal variants greatly benefits from haplotype reconstruction or phasing of genetic variants, but direct evidence for the haplotype structure is difficult to obtain from standard short-read sequencing data. Chromatin conformation data obtained from 3C experiments allows inference of haplotypes because inter-chromosomal contacts are more frequent than homologous intra-chromosomal contacts, but these data suffer from technical biases owing to the digestion and ligation process of the 3C technique. Genome Architecture Mapping (GAM) is a novel digestion- and ligation-free method for the inference of chromatin conformation from nuclear cryosections. Due to its high resolution and independence of enzymatic digestion it is well-suited for haplotype reconstruction and for detecting haplotype-specific chromatin contacts. Results: Here, we present GAMIBHEAR, a tool for accurate haplotype reconstruction from GAM data. GAMIBHEAR aggregates allelic co-observation frequencies across multiple nuclear slices and employs a GAM-specific probabilistic model of haplotype capture to optimise phasing accuracy. Using a hybrid mouse embryonic stem cell line with known haplotype structure as a benchmark dataset, we assess correctness and completeness of the reconstructed haplotypes, and demonstrate the power of GAM data and the accuracy of GAMIBHEAR to infer genome-wide haplotypes. Availability: GAMIBHEAR is available as an R package under the open source GPL-2 license at https://bitbucket.org/schwarzlab/gamibhear Maintainer: julia.markowski{at}mdc-berlin.d

Technical evaluation of proposed Ukrainian Central Radioactive Waste Processing Facility

This technical report is a comprehensive evaluation of the proposal by the Ukrainian State Committee on Nuclear Power Utilization to create a central facility for radioactive waste (not spent fuel) processing. The central facility is intended to process liquid and solid radioactive wastes generated from all of the Ukrainian nuclear power plants and the waste generated as a result of Chernobyl 1, 2 and 3 decommissioning efforts. In addition, this report provides general information on the quantity and total activity of radioactive waste in the 30-km Zone and the Sarcophagus from the Chernobyl accident. Processing options are described that may ultimately be used in the long-term disposal of selected 30-km Zone and Sarcophagus wastes. A detailed report on the issues concerning the construction of a Ukrainian Central Radioactive Waste Processing Facility (CRWPF) from the Ukrainian Scientific Research and Design institute for Industrial Technology was obtained and incorporated into this report. This report outlines various processing options, their associated costs and construction schedules, which can be applied to solving the operating and decommissioning radioactive waste management problems in Ukraine. The costs and schedules are best estimates based upon the most current US industry practice and vendor information. This report focuses primarily on the handling and processing of what is defined in the US as low-level radioactive wastes